Special Interest at ARVO

September 29, 2008 by · Leave a Comment 

The ARVO 2008 Annual Meeting, Eyes on Innovation, was held on April 27-May 1 in Fort Lauderdale, Florida.
The KPro group took advantage of this major meeting to hold a Special Interest Group focused on Keratoprostheses and Glaucoma. The session looked at new technologies associated with corneal prostheses including challenges, advancements and problems, with a special focus on glaucoma.

ARVO is a major forum for vision researchers and practitioners to explore the latest innovative techniques, protocols and tools in development and use by ophthalmic researchers whose quest is to improve patient care and vision and to cure eye diseases.

The SIG attracted many attendees in what proved to be a very interesting session.
The SIG was moderated by Claes Dohlman, Harvard Medical School, and Jean-Marie Parel, Bascom Palmer Eye Institute, University of Miami.
The SIG included presentations from:

  • Victor Perez: Opening comments & KPro’s today – types of implants, indications and problems with Glaucoma
  • Konrad Hille: Intraocular pressure measurements post KPro implantation
  • Cynthia Grosskreutz: Incidence and treatment options
  • Yale Fisher: Endoscopy & KPro
  • Paul Palmberg: Drainage implants

Evaluation of the Stability of Boston Keratoprosthesis Type I – Donor Cornea Interface Utilizing Anterior Segment Optical Coherence Tomography

September 29, 2008 by · Leave a Comment 

Author Block: J.P. Garcia, Jr.1A,2, D.C. Ritterband1,2, A. Ko1,2, J.A. Seedor1,2, D.F. Buxton1,2, J. De la Cruz3. ARetina Center, 1New York Eye & Ear Infirmary, New York, NY; 2New York Medical College, Valhalla, NY; 3Illinois Eye & Ear Infirmary, Chicago, IL.
Purpose: To evaluate the anatomic stability of an implanted Boston Type I Keratoprosthesis (KPro)-donor cornea interface, and assess the presence or absence of a potential space (gap) between the KPro front plate and donor cornea using anterior segment optical coherence tomography (AS- OCT). The presence of a gap would raise concerns of a possible pathway for the exchange of fluid between the ocular surface and the anterior chamber.

Methods: Fourteen eyes implanted with a Boston Type I KPro were studied by the non-contact technique of AS-OCT (AC Cornea OCT prototype, OTI, Canada). All the KPro devices had been implanted at least 4 weeks prior to the study (range: 1 to 22 months). Seven eyes had aphakic Kpros and the other 7 had pseudophakic implants. Anesthetized eyes were imaged before and during pressure application using sterile cotton tip applicators. Pressure was applied for 10 seconds just outside the temporal limbal area. Images were analyzed for any possible changes in the KPro-donor cornea interface during the application of pressure.

Results: Of 14 eyes, 10 had the threaded front plate model with a T-shaped silhouette and corrugated sides, whereas 4 had the threadless type with a T-shaped silhouette and smooth sides on cross-sectional OCT. Two of the 14 eyes revealed a gap between the front plate and the surface of the donor cornea, along with pooling of fluorescein within the gap. The rest revealed no gaps. With pressure, none of the eyes, including the two with gaps, demonstrated any change in the KPro-donor cornea interface during dynamic imaging (e.g. gaping, evidence of fluid entry or escape along the KPro-donor cornea borders). In all eyes, the titanium locking ring was visualized in its proper position.

Conclusions: The stability of an implanted KPro-donor cornea interface has been demonstrated dynamically utilizing AS-OCT. A gap that has been documented with this imaging tool showed neither extension nor exchange of fluid between the two environments during dynamic cross sectional imaging. All 14 eyes demonstrated proper positioning of the back plate and titanium locking ring, thus confirming that the phenomenon is not due to a loose fitting, unscrewing or improperly placed locking ring. Further studies will be needed to assess the cause of these gaps and determine if they are possibly related to the hydration status of the cornea, interaction of the cornea with prolonged use of a bandage contact lens or to other factors not yet determined.

Commercial Relationship: J.P. Garcia, OPKO, R; D.C. Ritterband, None; A. Ko, None; J.A. Seedor, None; D.F. Buxton, None; J. De la Cruz, None.

download poster – PDF

KPro SIS at EVER Conference, Portoroz, Slovenia

September 24, 2008 by · Leave a Comment 

KPro SIS at EVER Conference, Portoroz, Slovenia
Date: Saturday 4th October 2008
Location: Room – Emerald I
Time: 14:15-15:45 hrs
Special Interest Symposium (Keratoprostheses I)
Moderator: Christopher Liu
14:15-14:33 The narrowing choice of Keratoprostheses Liu C
14:33-14:51 Developing a recovery psychological model for patients undergoing KPro surgery Busuttil A, Liu C
14:51-15:09 More than 50 years experience with keratoprostheses Barraquer J
15:09-15:27 Biosynthetic corneas – an update Fagerholm P, Lagali N, Griffith M